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AI for microbial RNA (mbRNA)

I. AI models for RNA

  • 👍 [Roadmap] 2025 Nature Reviews - Decoding the interactions and functions of non-coding RNA with artificial intelligence
  • 2026 Nature - Advancing regulatory variant effect prediction with AlphaGenome
  • 👍 2024 Nature Machine Intelligence - An interpretable RNA foundation model for exploring functional RNA motifs in plants
  • New models
    • RiNALMo, HydraRNA, RNAErnie, Ernie-RNA, structRFM, ...

II. Microbial RNA Struture

mbRNAfinder

  • 👍 2021 Genome Biology - Comparative genomics identifies thousands of candidate structured RNAs in human microbiomes
  • 2024 Nature Biotechnology - RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
  • Database:

Ribozyme Design

(合作: Structure lab)

  • 2024 Nature Methods - [RfamGen]Deep generative design of RNA family sequences
  • 👍 2024 Nature machine intelligence - A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions