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AI for cell-free RNA (cfRNA)

I. cfRNA

  • 👍 2025 Nature Machine Intelligence - A multimodal cell-free RNA language model for liquid biopsy applications
  • 👍 2025 Nature - An ultrasensitive method for detection of cell-free RNA
  • 2025 Genome Biology - Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential [Lu Lab Paper]
  • 2023 Nature BME - Nature Profiling of repetitive RNA sequences in the blood plasma of patients with cancer
  • 👍 2022 eLife - Cancer Type Classification Using Plasma Cell Free RNAs Derived from Human and Microbes [Lu Lab Paper]
  • More cfRNA Studies
  • Database:

II. cfRNA - microbiome in blood

  • Virome & AI
    • 👍 2025 Nature Genetics - Blood DNA virome associates with autoimmune diseases and COVID-19
    • 👍 2024 Cell - Using Artificial Intelligence to Document the Hidden RNA Virosphere
  • cfRNA-microbial reads
    • 2025 Nature Biotechnology - Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples
    • 👍 2022 eLife - Cancer Type Classification Using Plasma Cell Free RNAs Derived from Human and Microbes [Lu Lab Paper]
    • 2020 Nature - RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach
      • concerns: Gihawi, A. et al. Major data analysis errors invalidate cancer microbiome findings. mBio 14, e01607–23 (2023)
      • response: Sepich-Poore, G. D. et al. Robustness of cancer microbiome signals over a broad range of methodological variation. Oncogene 43, 1127–1148 (2024).